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M94A2420.TXT
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Document 2420
DOCN M94A2420
TI Vertical transmission risk (VTR) of HIV-1 in Brazil: the impact of low
loss to follow-up.
DT 9412
AU Tess B; Rodrigues LC; Duarte G; Mussi-Pinhata MM; Cervi MC; Newell ML;
Instituto de Saude, SP, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):308 (abstract no. PC0160). Unique
Identifier : AIDSLINE ICA10/94370155
AB OBJECTIVES: 1. To estimate the VTR of HIV-1 in Ribeirao Preto, Brazil.
2. To investigate the impact of low loss to follow up on the VTR of
HIV-1. METHODS: An on-going retrospective (1988 to 1992) cohort study
identified 112 HIV-positive mothers tested antenatally or at delivery at
the University Hospital in Ribeirao Preto, Brazil. Children older than
18 months were assessed for HIV-infection through a serologic test
(ELISA). Infant deaths were classified as indeterminate (children with
unknown HIV infection status), HIV-related and non-HIV-related. A
previous estimate of the VTR was 29.5% (95% CI 20 to 39) and it was
based on a partially overlapping cohort but without intensive follow up.
RESULTS: Of 112, intensive searching resulted in contacting 97 (86.6%)
mother-child pairs; 2 study subjects refused to be tested and 6 children
were classified as indeterminate when they died. Seventy one children
were seronegative, 18 seropositive (7 of them died of AIDS). The VTR in
this cohort was 20.2% (95% CI 11.8 to 28.5). Of 23 children who had been
previously lost to follow up before 18 months of age and who were found
through the intensive searching, 22 were seronegative for HIV-1.
CONCLUSIONS: The VTR of HIV-1 in Ribeirao Preto (20.2%) was closer to
the risks estimated in Europe and the USA than to the risks estimated in
Africa. The large majority of children who lost contact with the health
services and who were found through an intensive searching were HIV-1
seronegative. Less comprehensive follow up would have led to a much
higher estimate of the VTR of HIV-1 in this cohort.
DE Brazil Cohort Studies Female Human HIV Infections/*TRANSMISSION
*HIV-1 Infant, Newborn Pregnancy *Pregnancy Complications, Infectious
Retrospective Studies Risk Factors MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).